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New Hotspot Detection Method Developed in CIA Lab

CIA Lab Researchers, in collaboration with the Department of Pathology at Ohio State University have developed a new method to segment Ki-67 positive nuclei and determine hotspots in the neuroendocrine tumour slide images. 

The publication, “Perceptual clustering for automatic hotspot detection from Ki-67 stained neuroendocrine tumour images” by Niazi, Yearsley, Zhou, Frankel, and Gurcan will be published in Journal of Microscopy. The methodology can be seen below.


This new method attempts to mimic the thought process of a pathologist. It was tested and had an accuracy of 94.60%. This methodology can also be applied to other disease studies in the future. 

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